Means to analyse cellular proteins and their millions of variants at the single-molecule level
would uncover substantial information previously unknown to biology. Nanopore …

Circulating tumor cells (CTCs) represent an interesting source of biomarkers for diagnosis,
prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in …

The electrical current blockade of a peptide or protein threading through a nanopore can be
used as a fingerprint of the molecule in biosensor applications. However, threading of full …

A molecular robot, which is a system comprised of one or more molecular machines and
computers, can execute sophisticated tasks in many fields that span from nanomedicine to …

Structural complexity of glycans derived from the diversities in composition, linage,
configuration, and branching considerably complicates structural analysis. Nanopore-based …

In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the
limitations of current biophysical approaches. Here, we develop a biological nanopore …

Nanopores are promising single-molecule tools for the electrical identification and
sequencing of biomolecules. However, the characterization of proteins, especially in real …

Nanopores are label-free single-molecule analytical tools that show great potential for
stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with …

There is a current need to develop methods for the sensitive detection of peptide biomarkers
in complex mixtures of molecules, such as biofluids, to enable early disease detection …

Simultaneous detection and structural characterization of protein variants on a single
platform are highly desirable but technically challenging. Herein, we present a single …