Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z Xie, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

S Zhang, L Wang, G Cheng - Molecular therapy, 2022 - cell.com
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

SARS-CoV-2 Omicron BA. 5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of …

A Aggarwal, A Akerman, V Milogiannakis, MR Silva… - …, 2022 - thelancet.com
Background Genetically distinct viral variants of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of …

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6

TY Taha, IP Chen, JM Hayashi, T Tabata… - Nature …, 2023 - nature.com
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

WJ Tu, M Melino, J Dunn, RD McCuaig… - Nature …, 2023 - nature.com
In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using
digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters …

Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations

Q Rafique, A Rehman, MS Afghan, HM Ahmad… - Computers in Biology …, 2023 - Elsevier
The COVID-19 pandemic has necessitated the development of reliable diagnostic methods
for accurately detecting the novel coronavirus and its variants. Deep learning (DL) …

In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects …

Y Furusawa, M Kiso, S Iida, R Uraki, Y Hirata, M Imai… - …, 2023 - thelancet.com
Summary Background The SARS-CoV-2 delta (B. 1.617. 2 lineage) variant was first
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …

Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction

SE Guimond, CJ Mycroft-West, NS Gandhi… - ACS central …, 2022 - ACS Publications
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with
the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new …

What Have We Learned by Resurrecting the 1918 Influenza Virus?

B Gilbertson, K Subbarao - Annual Review of Virology, 2023 - annualreviews.org
The 1918 Spanish influenza pandemic was one of the deadliest infectious disease events in
recorded history, resulting in approximately 50–100 million deaths worldwide. The origins of …