[HTML][HTML] Update on GPCR-based targets for the development of novel antidepressants
Traditional antidepressants largely interfere with monoaminergic transport or degradation
systems, taking several weeks to have their therapeutic actions. Moreover, a large …
systems, taking several weeks to have their therapeutic actions. Moreover, a large …
[HTML][HTML] Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents
Y He, I Kaya, R Shariatgorji, J Lundkvist… - Nature …, 2023 - nature.com
Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked
to Parkinson's disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post …
to Parkinson's disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post …
Evaluation of amide bioisosteres leading to 1, 2, 3-triazole containing compounds as GPR88 agonists: design, synthesis, and structure–activity relationship studies
MT Rahman, AM Decker, L Laudermilk… - Journal of medicinal …, 2021 - ACS Publications
The orphan receptor GPR88 has been implicated in a number of striatal-associated
disorders, yet its endogenous ligand has not been discovered. We have previously reported …
disorders, yet its endogenous ligand has not been discovered. We have previously reported …
Exploring orphan GPCRs in neurodegenerative diseases
Neurodegenerative disorders represent a significant and growing health burden worldwide.
Unfortunately, limited therapeutic options are currently available despite ongoing efforts …
Unfortunately, limited therapeutic options are currently available despite ongoing efforts …
Design, Synthesis, and Structure–Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl) acetamides Based on the Reversed Amide Scaffold
The development of synthetic agonists for the orphan receptor GPR88 has recently attracted
significant interest, given the promise of GPR88 as a novel drug target for psychiatric and …
significant interest, given the promise of GPR88 as a novel drug target for psychiatric and …
[HTML][HTML] TAAR1-dependent and-independent actions of tyramine in interaction with glutamate underlie central Effects of monoamine oxidase inhibition
I Mantas, T Vallianatou, Y Yang, M Shariatgorji… - Biological …, 2021 - Elsevier
Abstract Background Monoamine oxidase inhibitors (MAOIs) exert therapeutic actions by
elevating extracellular levels of monoamines in the brain. Irreversible MAOIs cause serious …
elevating extracellular levels of monoamines in the brain. Irreversible MAOIs cause serious …
Impaired working memory, cognitive flexibility and reward processing in mice genetically lacking Gpr88: evidence for a key role for Gpr88 in multiple cortico‐striatal …
DM Thomson, RL Openshaw, EJ Mitchell… - Genes, Brain and …, 2021 - Wiley Online Library
The GPR88 orphan G protein‐coupled receptor is expressed throughout the striatum, being
preferentially localised in medium spiny neurons. It is also present in lower densities in …
preferentially localised in medium spiny neurons. It is also present in lower densities in …
Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor
AM Decker, MT Rahman, CM Kormos, D Hesk… - Bioorganic & medicinal …, 2023 - Elsevier
GPR88 is an orphan G protein-coupled receptor which has been implicated in a number of
striatal-associated disorders. Herein we describe the synthesis and pharmacological …
striatal-associated disorders. Herein we describe the synthesis and pharmacological …
A Review of Neuroreceptors for Clinical and Experimental Neuropharmacology in Central Nervous System Disorders
SC McKarns - Current Reviews in Clinical and Experimental …, 2023 - ingentaconnect.com
The neurobiology drug discovery landscape has transformed over the past decade or so by
the discovery of allosteric modulators of receptor superfamilies. A wide range of …
the discovery of allosteric modulators of receptor superfamilies. A wide range of …
[图书][B] Regulation of Monoaminergic Functions by Gpcrs with a Special Emphasis on Mental and Movement Disorders
I Mantas - 2022 - search.proquest.com
Dysfunction of the brain's monoaminergic system has been implicated in many human
neurological and psychiatric disorders, such as Parkinson's disease (PD), major depressive …
neurological and psychiatric disorders, such as Parkinson's disease (PD), major depressive …