Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …

Background The global dissemination of colistin resistance encoded by mcr-1 has been
attributed to extensive use of colistin in livestock, threatening colistin efficacy in medicine …

Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the
advances made by modern medical care over the past century. The World Health …

Colistin resistance has attracted substantial attention after colistin was considered as a last‐
resort drug for the treatment of infections caused by carbapenem‐resistant and/or multidrug …

Objectives To identify the molecular mechanism of colistin resistance in an MDR
Acinetobacter baumannii clinical strain isolated in 2008 from a meningitis case in Brazil …

Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) are plasmid-encoded genes that
threaten the clinical utility of colistin (COL), one of the highest-priority critically important …

Since 2015, new worrying colistin resistance mechanism, mediated by mcr-1 gene has been
reported worldwide along with eight newly described variants but their source (s) and …