Mobile genetic elements associated with antimicrobial resistance
SR Partridge, SM Kwong, N Firth… - Clinical microbiology …, 2018 - Am Soc Microbiol
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …
increasing major health care problem around the world. It is now abundantly clear that both …
Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance
C Ayoub Moubareck - Membranes, 2020 - mdpi.com
Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
Global burden of colistin-resistant bacteria: mobilized colistin resistance genes study (1980–2018)
M Elbediwi, Y Li, N Paudyal, H Pan, X Li, S Xie… - Microorganisms, 2019 - mdpi.com
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …
Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross …
C Shen, LL Zhong, Y Yang, Y Doi, DL Paterson… - The Lancet …, 2020 - thelancet.com
Background The global dissemination of colistin resistance encoded by mcr-1 has been
attributed to extensive use of colistin in livestock, threatening colistin efficacy in medicine …
attributed to extensive use of colistin in livestock, threatening colistin efficacy in medicine …
Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update
M Mmatli, NM Mbelle, J Osei Sekyere - Frontiers in Cellular and …, 2022 - frontiersin.org
Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …
Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae
Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the
advances made by modern medical care over the past century. The World Health …
advances made by modern medical care over the past century. The World Health …
Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes
Colistin resistance has attracted substantial attention after colistin was considered as a last‐
resort drug for the treatment of infections caused by carbapenem‐resistant and/or multidrug …
resort drug for the treatment of infections caused by carbapenem‐resistant and/or multidrug …
A novel plasmid-encoded mcr-4.3 gene in a colistin-resistant Acinetobacter baumannii clinical strain
N Martins-Sorenson, E Snesrud… - Journal of …, 2020 - academic.oup.com
Objectives To identify the molecular mechanism of colistin resistance in an MDR
Acinetobacter baumannii clinical strain isolated in 2008 from a meningitis case in Brazil …
Acinetobacter baumannii clinical strain isolated in 2008 from a meningitis case in Brazil …
Mobile Colistin Resistance (mcr) Gene-Containing Organisms in Poultry Sector in Low- and Middle-Income Countries: Epidemiology, Characteristics, and One Health …
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) are plasmid-encoded genes that
threaten the clinical utility of colistin (COL), one of the highest-priority critically important …
threaten the clinical utility of colistin (COL), one of the highest-priority critically important …
Massive analysis of 64,628 bacterial genomes to decipher water reservoir and origin of mobile colistin resistance genes: is there another role for these enzymes?
MB Khedher, SA Baron, T Riziki, R Ruimy, D Raoult… - Scientific reports, 2020 - nature.com
Since 2015, new worrying colistin resistance mechanism, mediated by mcr-1 gene has been
reported worldwide along with eight newly described variants but their source (s) and …
reported worldwide along with eight newly described variants but their source (s) and …