The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …

Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Diabetic kidney disease (DKD) remains a leading cause of new-onset end-stage renal
disease (ESRD), and yet, at present, the treatment is still very limited. A better understanding …

A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed
commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin …

The mammalian kidney develops through reciprocal interactions between the ureteric bud
and the metanephric mesenchyme to give rise to the entire collecting system and the …

Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal
surface of microvessels, where they provide structural and biochemical support. Pericytes …

Chemokines were recognized originally for their ability to dictate the migration and activation
of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell …

Human induced pluripotent stem cell-derived kidney organoids have potential for disease
modeling and to be developed into clinically transplantable auxiliary tissue. However, they …