Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …

Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …

Background Although both long and micro RNAs are emerging as important functional
components in colorectal cancer (CRC) progression and metastasis, the mechanism of their …

With the identification of huge amount of noncoding RNAs in recent years, the concept of
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …

MicroRNAs (miRNAs) are a group of small non-coding RNAs present in a wide diversity of
organisms. MiRNAs regulate gene expression at a post-transcriptional level through their …

Ischemia/reperfusion injury (IRI) initiates from oxidative stress caused by lack of blood
supply and subsequent reperfusion. It is often associated with sterile inflammation, cell …

The fecundity of female mammals is resolved by the limited size of the primordial follicle (PF)
pool formed perinatally. The establishment of PF pool is accompanied by a significant …