Karyopherin-mediated nucleocytoplasmic transport
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …
The nuclear export protein XPO1—from biology to targeted therapy
AS Azmi, MH Uddin, RM Mohammad - Nature reviews Clinical oncology, 2021 - nature.com
Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
L Chen, Y Wang, J Lin, Z Song, Q Wang… - Nature …, 2022 - nature.com
Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …
XPO1-dependent nuclear export as a target for cancer therapy
NG Azizian, Y Li - Journal of hematology & oncology, 2020 - Springer
Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …
A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells
Y Yu, P Nangia-Makker, L Farhana, APN Majumdar - Molecular cancer, 2017 - Springer
Background Although both long and micro RNAs are emerging as important functional
components in colorectal cancer (CRC) progression and metastasis, the mechanism of their …
components in colorectal cancer (CRC) progression and metastasis, the mechanism of their …
Mechanisms of RNA export and nuclear retention
M Khan, S Hou, M Chen, H Lei - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
With the identification of huge amount of noncoding RNAs in recent years, the concept of
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …
MicroRNAs: Master regulators in host–parasitic protist interactions
M Rojas-Pirela, D Andrade-Alviárez… - Open …, 2022 - royalsocietypublishing.org
MicroRNAs (miRNAs) are a group of small non-coding RNAs present in a wide diversity of
organisms. MiRNAs regulate gene expression at a post-transcriptional level through their …
organisms. MiRNAs regulate gene expression at a post-transcriptional level through their …
MicroRNA mediated regulation of the major redox homeostasis switch, Nrf2, and its impact on oxidative stress-induced ischemic/reperfusion injury
G Padmavathi, KM Ramkumar - Archives of Biochemistry and Biophysics, 2021 - Elsevier
Ischemia/reperfusion injury (IRI) initiates from oxidative stress caused by lack of blood
supply and subsequent reperfusion. It is often associated with sterile inflammation, cell …
supply and subsequent reperfusion. It is often associated with sterile inflammation, cell …
Long non-coding RNA Xist regulates oocyte loss via suppressing miR-23b-3p/miR-29a-3p maturation and upregulating STX17 in perinatal mouse ovaries
M Zhou, X Liu, E Qiukai, Y Shang, X Zhang, S Liu… - Cell death & …, 2021 - nature.com
The fecundity of female mammals is resolved by the limited size of the primordial follicle (PF)
pool formed perinatally. The establishment of PF pool is accompanied by a significant …
pool formed perinatally. The establishment of PF pool is accompanied by a significant …