Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

The activation of fibroblasts is required for physiological tissue remodelling such as wound
healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain …

The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed
the proteome and metabolome of urine and serum samples from patients with COVID-19 …

Cell surface receptors are important proteins that mediate communication between the cells
and their outside environment, and also play essential roles in the control of a wide variety of …

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3), a receptor tyrosine kinase
encoded by the FLT4 gene, plays a significant role in the morphogenesis and maintenance …

Systemic sclerosis (SSc) is an idiopathic autoimmune disease with a heterogeneous clinical
phenotype ranging from limited cutaneous involvement to rapidly progressive diffuse SSc …

Previously we have shown that several oxidative stress-driven pathways in cutaneous
chronic wounds are dysregulated in the first 48 h post-wounding. Here, we performed an …

Liver fibrosis is a pathological process characterized by the excessive synthesis and
accumulation of extracellular matrix proteins (ECMs) contributed mainly by the activated …

Abstract Erythropoietin producing hepatocellular (Eph)–Eph receptor interacting (Ephrin)
receptor–ligand signaling has been implicated in the development of tissue fibrosis, though …

Pulmonary fibrosis is the end-stage change of a large class of lung diseases characterized
by the proliferation of fibroblasts and the accumulation of a large amount of extracellular …