The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
Targeting the gut to treat multiple sclerosis
L Ghezzi, C Cantoni, GV Pinget… - The Journal of clinical …, 2021 - Am Soc Clin Investig
The gut-brain axis (GBA) refers to the complex interactions between the gut microbiota and
the nervous, immune, and endocrine systems, together linking brain and gut functions …
the nervous, immune, and endocrine systems, together linking brain and gut functions …
[HTML][HTML] Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia
CA Olson, AJ Iñiguez, GE Yang, P Fang… - Cell host & …, 2021 - cell.com
Many genetic and environmental factors increase susceptibility to cognitive impairment (CI),
and the gut microbiome is increasingly implicated. However, the identity of gut microbes …
and the gut microbiome is increasingly implicated. However, the identity of gut microbes …
Emerging role of hepatic ketogenesis in fatty liver disease
RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …
Local cholesterol metabolism orchestrates remyelination
Cholesterol is an essential component of all cell membranes and particularly enriched in
myelin membranes. Myelin membranes are a major target of immune attacks in the chronic …
myelin membranes. Myelin membranes are a major target of immune attacks in the chronic …
Ketogenic diet uncovers differential metabolic plasticity of brain cells
T Düking, L Spieth, SA Berghoff, L Piepkorn… - Science …, 2022 - science.org
To maintain homeostasis, the body, including the brain, reprograms its metabolism in
response to altered nutrition or disease. However, the consequences of these challenges for …
response to altered nutrition or disease. However, the consequences of these challenges for …
The effects of dietary interventions on brain aging and neurological diseases
F Lobo, J Haase, S Brandhorst - Nutrients, 2022 - mdpi.com
Dietary interventions can ameliorate age-related neurological decline. Decades of research
of in vitro studies, animal models, and clinical trials support their ability and efficacy to …
of in vitro studies, animal models, and clinical trials support their ability and efficacy to …
The relationship of ketogenic diet with neurodegenerative and psychiatric diseases: a scoping review from basic research to clinical practice
Background: The ketogenic diet (KD) has become widespread for the therapy of epileptic
pathology in childhood and adulthood. In the last few decades, the current re-emergence of …
pathology in childhood and adulthood. In the last few decades, the current re-emergence of …
Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits
JN Brenton, D Lehner-Gulotta, E Woolbright… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background Dietary changes impact human physiology and immune function and have
potential as therapeutic strategies. Objective Assess the tolerability of a ketogenic diet (KD) …
potential as therapeutic strategies. Objective Assess the tolerability of a ketogenic diet (KD) …
Cuprizone-induced demyelination in mouse hippocampus is alleviated by ketogenic diet
C Liu, N Zhang, R Zhang, L Jin… - Journal of Agricultural …, 2020 - ACS Publications
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Recently, ketogenic diet (KD) supplementation has attracted great …
nervous system (CNS). Recently, ketogenic diet (KD) supplementation has attracted great …