Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …

Backgrounds & Aims Increased permeability is implicated in the pathogenesis of intestinal
disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein …

Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …

Defective epithelial barrier function is present in maladies including epidermal burn injury,
environmental lung damage, renal tubular disease, and a range of immune-mediated and …

The tight junction protein claudin-2 is upregulated in disease. Although many studies have
linked intestinal barrier loss to local and systemic disease, these have relied on …

Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient
absorption and prevents pathogenic entry, harmful metabolites, and endotoxin absorption …

Intestinal barrier function is required for the maintenance of mucosal homeostasis. Barrier
dysfunction is thought to promote progression of both intestinal and systemic diseases. In …

The intestinal barrier is an essential component of innate host defense. The single layer of
epithelial cells that line the intestine must balance barrier function with both active …

There are some challenges and unmet needs in the early diagnosis and management of
Sjögren's syndrome (SjS) such as prominent glandular dysfunction at diagnosis and long …