The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

The adaptive immune response meets the needs of the organism to generate effector cells
capable of controlling pathogens but also leads to production of memory cells, which …

In an adaptive immune response, naive T cells proliferate during infection and generate long-
lived memory cells that undergo secondary expansion after a repeat encounter with the …

Adoptive-transfer experiments with relatively large input numbers (∼ 10 6) of T cell receptor-
transgenic (TCR-tg) T cells are widely used to model endogenous T cell responses to …

Efficient boosting of memory T-cell numbers to protective levels generally requires a
relatively long interval between immunizations. Decreasing this interval could be crucial in …

Repetitive antigen stimulation by prime-boost vaccination or pathogen reencounter
increases memory CD8+ T cell numbers, but the impact on memory CD8+ T cell …

The contributions of different subsets of memory CD8+ T cells to recall responses at mucosal
sites of infection are poorly understood. Here, we analyzed the CD8+ T cell recall responses …

Heterologous prime-boost vaccination results in increased frequencies of memory T cells.
Although these quantitative effects of reexposure to Ag are well documented, little is known …

CD8+ T cells (also called cytotoxic T lymphocytes) play a major role in protective immunity
against many infectious pathogens and can eradicate malignant cells. The path from naive …

Although the absolute number of memory CD8+ T cells established in the spleen following
antigen encounter remains stable for many years, the relative capacity of these cells to …