Cell-penetrating peptides: design, synthesis, and applications

DM Copolovici, K Langel, E Eriste, U Langel - ACS nano, 2014 - ACS Publications
The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

[HTML][HTML] Cell-penetrating peptides: 20 years later, where do we stand?

C Bechara, S Sagan - FEBS letters, 2013 - Elsevier
Twenty years ago, the discovery of peptides able to cross cellular membranes launched a
novel field in molecular delivery based on these non-invasive vectors, most commonly …

Translocation mechanism (s) of cell-penetrating peptides: biophysical studies using artificial membrane bilayers

M Di Pisa, G Chassaing, JM Swiecicki - Biochemistry, 2015 - ACS Publications
The ability of cell-penetrating peptides (CPPs) to cross cell membranes has found numerous
applications in the delivery of bioactive compounds to the cytosol of living cells. Their …

Effects of Tryptophan Content and Backbone Spacing on Uptake Efficiency of Cell-Penetrating Peptides

HA Rydberg, M Matson, HL Åmand, EK Esbjörner… - Biophysical …, 2012 - cell.com
Cell-penetrating peptides (CPPs) have recently gained considerable interest due to their
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …

Endocytic trafficking of nanoparticles delivered by cell-penetrating peptides comprised of nona-arginine and a penetration accelerating sequence

BR Liu, SY Lo, CC Liu, CL Chyan, YW Huang… - PloS one, 2013 - journals.plos.org
Cell-penetrating peptides (CPPs) can traverse cellular membranes and deliver biologically
active molecules into cells. In this study, we demonstrate that CPPs comprised of nona …

Elementary processes for the entry of cell-penetrating peptides into lipid bilayer vesicles and bacterial cells

MZ Islam, S Sharmin, M Moniruzzaman… - Applied microbiology and …, 2018 - Springer
Cell-penetrating peptides (CPPs) can translocate across the plasma membrane of living
eukaryotic cells and enter the cytosol without significantly affecting cell viability …

Translocation of polyarginines and conjugated nanoparticles across asymmetric membranes

Z Li, H Ding, Y Ma - Soft Matter, 2012 - pubs.rsc.org
Understanding how cell-penetrating peptides translocate across cell membranes is of great
importance in biomedicine. In this paper, we study the interactions between polyarginines …

Interactions between membranes and “metaphilic” polypeptide architectures with diverse side-chain populations

MW Lee, M Han, GV Bossa, C Snell, Z Song, H Tang… - ACS …, 2017 - ACS Publications
At physiological conditions, most proteins or peptides can fold into relatively stable
structures that present on their molecular surfaces specific chemical patterns partially …

The interfacial electrostatic potential modulates the insertion of cell-penetrating peptides into lipid bilayers

MA Via, J Klug, N Wilke, LS Mayorga… - Physical Chemistry …, 2018 - pubs.rsc.org
Cell-penetrating peptides (CPP) are short sequences of cationic amino-acids that show a
surprising ability to traverse lipid bilayers. CPP are considered to be some of the most …

Influence of temperature on molecular adsorption and transport at liposome surfaces studied by molecular dynamics simulations and second harmonic generation …

P Hamal, V Subasinghege Don… - The Journal of …, 2021 - ACS Publications
A fundamental understanding of the kinetics and thermodynamics of chemical interactions at
the phospholipid bilayer interface is crucial for developing potential drug-delivery …