Traditional cancer chemotherapy easily produces serious toxic and side effects due to the
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …

Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …

For many decades classical anti-tumor therapies included chemotherapy, radiation and
surgery; however, in the last two decades, following the identification of the genomic drivers …

Recently, molecular hybridization paradigm became an interesting and smart way to defeat
the multifaceted cancer disease by a single molecular entity that acts via several …

In our attempt to develop effective EGFR-TKIs, two series of 1H-pyrazolo [3, 4-d] pyrimidine
derivatives were designed and synthesized. All the newly synthesized compounds were …

Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …

The epidermal growth factor receptor (EGFR) plays a critical role in the tumorigenesis of
various forms of cancer. Targeting the mutant forms of EGFR has been identified as an …

Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …

The 4-aminoquinazoline core is an interesting pharmacophore and its applications in
medicinal chemistry are wide spread. The core has been used for making many kinase …

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …