The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

The cell wall component lipoarabinomannan (ManLAM) from Mycobacterium tuberculosis is
involved in the inhibition of phagosome maturation, apoptosis and interferon (IFN)‐γ …

Human alveolar macrophages (AMφ) undergo apoptosis following infection with
Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens …

The liver X receptors (LXRs) are nuclear receptors with established roles in the regulation of
lipid metabolism. We now show that LXR signaling not only regulates macrophage …

Protective immunity against Mycobacterium tuberculosis involves major histocompatibility
complex class I (MHC-I)-and CD1-restricted CD8 T cells, but the mechanisms underlying …

We report that chlamydiae, which are obligate intracellular bacterial pathogens, possess a
novel antiapoptotic mechanism. Chlamydia-infected host cells are profoundly resistant to …

Infection by Mycobacterium tuberculosis (MTB) induces human alveolar macrophage (AMφ)
apoptosis by a TNF-α-dependent mechanism. The apoptotic response is postulated to be a …

The survival and persistence of Mycobacterium tuberculosis depends on its capacity to
manipulate multiple host defense pathways, including the ability to actively inhibit the death …

The role of alveolar macrophages (AM) in host defense against pulmonary infection has
been difficult to establish using in vivo models. This may reflect a reliance on models of …

Phagocytic leukocytes such as neutrophils and macrophages are essential for the innate
immune response against invading bacteria. Binding and ingestion of bacteria by these host …