Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Deciphering mechanisms of endocrine cell induction, specification and lineage allocation in
vivo will provide valuable insights into how the islets of Langerhans are generated …

Stem cell-derived insulin-producing beta cells (SC-β) offer an inexhaustible supply of
functional β cells for cell replacement therapies and disease modeling for diabetes. While …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …

The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …

Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal
cancer in the western world. There is substantial evidence implying that insulin and insulin …

The intestinal epithelium is largely maintained by self-renewing stem cells but with
apparently committed progenitors also contributing, particularly following tissue damage …

Adult neurogenesis is involved in cognitive performance but studies that manipulated this
process to improve brain function are scarce. Here, we characterized a genetic mouse …