Over the past 20 years, many efforts have been made to develop a vaccine against AIDS.
The lack of an animal model that can be productively infected with HIV-1 has been partially …

Abstract Analysis of indinavir levels in HIV-positive patients indicated that drug
concentrations in lymph node mononuclear cells (LNMCs) were about 25–35% of …

Abstract Purpose of Review Perinatal HIV-1 infection is associated with an increased risk for
neurologic impairments. With limited access to clinical specimens, animal models could …

We developed a SHIV/macaque model of transmission from infected dams to their infants.
Ten pregnant dams were infected intravenously with 100 MID50 of macaque‐titered SHIV …

Abstract The Infant Primate Research Laboratory (IPRL) was established in 1970 at the
University of Washington as a visionary project of Dr. Gene (Jim) P. Sackett. Supported by a …

Introduction 3. Lentivirus animal models 3.1. Murine models of perinatal transmission 3.2.
Feline models of perinatal transmission 3.3. Nonhuman primate models of perinatal …

Lentivirus-infected nonhuman primates exhibit behavioral and neurological pathology
similar to human immunodeficiency virus (HIV)-infected humans and offer a means to …

Objective: To determine which route of inoculation produced consistent and frequent HIV
infection in the central nervous system (CNS) and alterations in cognitive and motor …

Using a well-characterized fetal rhesus monkey model, simian immunodeficiency virus (SIV)
infection of hematopoietic stem cells (HSCs) and stromal cells was investigated to …

Abstract In 2009, an estimated 370,000 children contracted HIV from their mothers during
the perinatal and breastfeeding period [1]. Major progress has been made in reducing …