Microvascular dysfunction and hyperglycemia: a vicious cycle with widespread consequences

CDA Stehouwer - Diabetes, 2018 - Am Diabetes Assoc
Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

Early detection of diabetic retinopathy

H Safi, S Safi, A Hafezi-Moghadam… - Survey of ophthalmology, 2018 - Elsevier
Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes
mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that …

[HTML][HTML] Predicting the risk of developing diabetic retinopathy using deep learning

A Bora, S Balasubramanian, B Babenko… - The Lancet Digital …, 2021 - thelancet.com
Background Diabetic retinopathy screening is instrumental to preventing blindness, but
scaling up screening is challenging because of the increasing number of patients with all …

Prevalence of diabetic retinopathy in various ethnic groups: a worldwide perspective

S Sivaprasad, B Gupta, R Crosby-Nwaobi… - Survey of ophthalmology, 2012 - Elsevier
The alarming rise in diabetes prevalence is a global public health and economic problem.
Diabetic retinopathy is the most common complication of diabetes and the leading cause of …

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

R Robinson, VA Barathi, SS Chaurasia… - Disease models & …, 2012 - journals.biologists.com
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
one of the major causes of blindness worldwide. The pathogenesis of DR has been …

Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?

TM Curtis, TA Gardiner, AW Stitt - Eye, 2009 - nature.com
Retinopathy is a major complication of diabetes mellitus and this condition remains a
leading cause of blindness in the working population of developed countries. As diabetic …

Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms

SK Gupta, B Kumar, TC Nag, SS Agrawal… - Journal of Ocular …, 2011 - liebertpub.com
Purpose: The purpose of this study was to evaluate the therapeutic potential of oral curcumin
(1 g/kg body weight of rat) in the prevention and treatment of streptozotocin-induced diabetic …

[HTML][HTML] Retinal vascular caliber as a biomarker for diabetes microvascular complications

MK Ikram, CY Cheung, M Lorenzi, R Klein… - Diabetes …, 2013 - ncbi.nlm.nih.gov
Globally, the number of people with diabetes is expected to reach 552 million in 2030 (1).
Both the macrovascular (coronary artery disease, peripheral artery disease, and stroke) and …

The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure

G Liew, JJ Wang, N Cheung, YP Zhang, W Hsu… - Ophthalmology, 2008 - Elsevier
OBJECTIVE: Fractals represent a type of derived geometric pattern that permits the
characterization of the branching pattern of retinal vessels. We examined a new …

Quantitative assessment of early diabetic retinopathy using fractal analysis

N Cheung, KC Donaghue, G Liew, SL Rogers… - Diabetes …, 2009 - Am Diabetes Assoc
OBJECTIVE—Fractal analysis can quantify the geometric complexity of the retinal vascular
branching pattern and may therefore offer a new method to quantify early diabetic …