Therapeutic targeting of exportin-1 beyond nuclear export
YF Chen, DJ Adams - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Exportin-1 (XPO1), also known as chromosome region maintenance 1 (CRM1),
directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking …
directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking …
Electrophile determines cellular phenotypes among XPO1-targeting small molecules
YF Chen, Y Shen, DF Yan, M Ghazala… - Journal of Medicinal …, 2024 - ACS Publications
Covalent drug discovery has experienced a renaissance, with numerous electrophilic small
molecules recently gaining FDA approval. Many structurally diverse electrophilic small …
molecules recently gaining FDA approval. Many structurally diverse electrophilic small …
C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function
YF Chen, A Rahman, JL Sax, MJA Pleshinger… - Cell Chemical …, 2024 - cell.com
Molecular glues can induce proximity between a target protein and ubiquitin ligases to
induce target degradation, but strategies for their discovery remain limited. We screened …
induce target degradation, but strategies for their discovery remain limited. We screened …
Targeting XPO1 for fighting relapsed/refractory diseases: The research progress of XPO1 inhibitors
YQ Li, Z Fang, W Zhang, GW Rao, Q Zheng - Bioorganic Chemistry, 2024 - Elsevier
XPO1 is an influential member of the nuclear transporter protein family. The proteins and
RNA transported by XPO1 are related to the occurrence and development of many diseases …
RNA transported by XPO1 are related to the occurrence and development of many diseases …
Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein
WK Aumann, R Kazi, AM Harrington… - Oncology Reviews, 2024 - frontiersin.org
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein
that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore …
that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore …
Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes
Y Wu, Y Gou, T Wang, P Li, Y Li, X Lu, W Li… - International …, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) poses a significant health threat
characterized by lung inflammation primarily triggered by pulmonary monocytes. Despite the …
characterized by lung inflammation primarily triggered by pulmonary monocytes. Despite the …