A decade has passed since the first topical prostaglandin analog was prescribed to reduce
intraocular pressure (IOP) for the treatment of glaucoma. Now four prostaglandin analogs …

Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible
blindness in the world. Animal models of glaucoma are essential to our continued efforts of …

Once considered too difficult to use for glaucoma studies, mice are now becoming a
powerful tool in the research of the molecular and pathological events associated with this …

Purpose.: To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT)
in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including …

The purpose of this study was to improve a mouse model of chronic intraocular pressure
(IOP) elevation utilizing microbead injection in two strains of mice and to assess the effect of …

Elevated intraocular pressure (IOP) is the best recognized risk factor for the pathogenesis of
glaucoma and the extent of retinal ganglion cell (RGC) degeneration in glaucoma is closely …

Purpose: We evaluated differences in aqueous humor dynamics (AHD) among several
mouse strains within younger and older age groups. Methods: Albino (A/J, BALB/cJ) and …

Purpose:: Ocular lymphatics have been recently shown to contribute to aqueous humor
outflow. It is not yet known whether lymphatic outflow can be stimulated by pharmacological …

Glaucoma is a leading cause of blindness in the world, often associated with elevated eye
pressure. Currently, all glaucoma treatments aim to lower eye pressure by improving fluid …

Purpose: To compare the effects of both injectable anesthesia (ketamine/dexmedetomidine
versus ketamine/xylazine) and inhalant anesthesia (isoflurane) on IOP using continuous …