It is becoming increasingly apparent that the risk of developing osteoporosis is accrued
throughout the entire lifecourse, even from as early as conception. Thus early growth is …

Next‐generation sequencing (NGS) technologies have greatly impacted on every field of
molecular research mainly because they reduce costs and increase throughput of DNA …

Phenotypic plasticity is the production of multiple phenotypes from a single genome and is
notably observed in social insects. Multiple epigenetic mechanisms have been associated …

Neonicotinoids are effective insecticides used on many important arable and horticultural
crops. They are nicotinic acetylcholine receptor agonists which disrupt the function of insect …

Motivated by a DNA methylation application, this article addresses the problem of fitting and
inferring a multivariate binomial regression model for outcomes that are contaminated by …

Vitamin D has important roles in calcium metabolism and in the prevention of rickets and
osteomalacia. There is also increasing evidence to suggest a role for vitamin D in …

Identifying disease-associated changes in DNA methylation can help us gain a better
understanding of disease etiology. Bisulfite sequencing allows the generation of high …

Background The ageing process is a multifaceted phenomenon marked by the gradual
deterioration of cellular and organismal functions, accompanied by an elevated …

Abstract Background RNA sequencing (RNA-Seq) is a powerful technique for transcriptome
profiling of the organisms that uses the capabilities of next-generation sequencing (NGS) …

We consider the assessment of DNA methylation profiles for sequencing-derived data from a
single cell type or from cell lines. We derive a kernel smoothed EM-algorithm, capable of …