Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?
E Preger-Ben Noon, N Frankel - Essays in Biochemistry, 2022 - portlandpress.com
Animal genomes are compartmentalized into insulated regulatory units named topology-
associated domains (TADs). TADs insulate gene promoters from enhancers that occupy …
associated domains (TADs). TADs insulate gene promoters from enhancers that occupy …
Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles
M Herzog, E Alonso-Perez, I Salguero… - Nucleic acids …, 2021 - academic.oup.com
A single amino acid residue change in the exonuclease domain of human DNA polymerase
ϵ, P286R, is associated with the development of colorectal cancers, and has been shown to …
ϵ, P286R, is associated with the development of colorectal cancers, and has been shown to …
Mutation bias and GC content shape antimutator invasions
A Couce, O Tenaillon - Nature communications, 2019 - nature.com
Mutators represent a successful strategy in rapidly adapting asexual populations, but theory
predicts their eventual extinction due to their unsustainably large deleterious load. While …
predicts their eventual extinction due to their unsustainably large deleterious load. While …
Genome instability footprint under rapamycin and hydroxyurea treatments
The mutational processes dictating the accumulation of mutations in genomes are shaped
by genetic background, environment and their interactions. Accurate quantification of …
by genetic background, environment and their interactions. Accurate quantification of …
YeastIT: reducing mutational bias for in vivo directed evolution using a novel yeast mutator strain based on dual adenine-/cytosine-targeting and error-prone DNA …
Engineering proteins with new functions and properties often requires navigating large
sequence spaces through rounds of iterative improvement. However, a disparity exists …
sequence spaces through rounds of iterative improvement. However, a disparity exists …