Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of
congenital disease and infection in immunocompromised patients. T. gondii shares several …

The acquisition and storage of metals has been a preoccupation of life for millennia.
Transition metals, in particular iron, copper and zinc, have vital roles within cells. However …

Iron is a trace metal element that is essential for the survival of cells and parasites. The role
of iron in cerebral toxoplasmosis (CT) is still unclear. Deferiprone (DFP) is the orally active …

Abstract Background Although the 2019 EULAR/ACR classification criteria for systemic
lupus erythematosus (SLE) has required at least a positive anti-nuclear antibody (ANA) titer …

Toxoplasma gondii is an obligate intracellular parasite responsible for a pathology called
toxoplasmosis, which primarily affects immunocompromised individuals and developing …

Host iron deficiency is protective against severe malaria as the human malaria parasite
Plasmodium falciparum depends on bioavailable iron from its host to proliferate. The …

The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs
considerably from the ETC of the animals that these parasites infect, and is the target of …

The research field to identify and characterize genes essential for in vivo virulence in
Toxoplasma gondii has been dramatically advanced by a series of in vivo clustered …

Iron is required to support almost all life; however, levels must be carefully regulated to
maintain homeostasis. Although the obligate parasite Toxoplasma gondii requires iron, how …

Iron‑sulfur cluster are ubiquitous and ancient protein cofactors that support a wide array of
essential cellular functions. In eukaryotes, their assembly requires specific and dedicated …