Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Tumor immunotherapy is only effective in a fraction of patients due to a low response rate
and severe side effects, and these challenges of immunotherapy in clinics can be addressed …

Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers
great opportunities for exploring the use of copper‐based nanomaterials inducing …

One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic
efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …