The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …

Pathogenic bacteria cause various infections worldwide, especially in immunocompromised
and other susceptible individuals, and are also associated with high infant mortality rates in …

K-RAS is a highly relevant oncogene that is mutated in approximately 90% of pancreatic
cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new …

Activating mutants of RAS are commonly found in human cancers, but to date selective
targeting of RAS in the clinic has been limited to KRAS (G12C) through covalent inhibitors …

miRNAs are some of the most well-characterized regulators of gene expression. Integral to
several physiological processes, their aberrant expression often drives the pathogenesis of …

There are strong incentives for human populations to develop antiviral systems. Similarly,
genomes that encode antiviral systems have had strong selective advantages. Protein …

Simple Summary Researchers have spent nearly two decades unraveling the roles of non-
coding RNAs in cancer biology. In recent years, deep transcriptomic profiling of tissue and …

Genomically-informed therapy requires consideration of the functional impact of genomic
alterations on protein expression and/or function. However, a substantial number of variants …

More than six decades ago Watson and Crick published the chemical structure of DNA. This
discovery revolutionized our approach to medical science and opened new perspectives for …

An amino acid exchange (P209L) in the HSPB8 binding site of the human co-chaperone
BAG3 gives rise to severe childhood cardiomyopathy. To phenocopy the disease in mice …