Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

The purpose of this narrative review is to summarize evidence of the epidemiology of and
risk factors for kidney cancer with a focus on renal cell carcinoma in adults. The etiology of …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

Context International variations in the rates of kidney cancer (KC) are considerable. An
understanding of the risk factors for KC development is necessary to generate opportunities …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Large-scale human genetic data,–have shown that cancer mutations display strong tissue-
selectivity, but how this selectivity arises remains unclear. Here, using experimental models …

BRD4 has long been implicated in many different pathological processes, in particular, the
development of cancer and inflammation. Pyroptosis is a newly recognized type of …

Clear cell renal cell carcinoma (ccRCC) is characterized by large intracellular lipid droplets
containing free and esterified cholesterol; however, the functional significance of cholesterol …

Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …

Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by deregulated
hypoxia-inducible factor signaling, mutation of several key chromatin modifying enzymes …