Recent developments of chalcones as potential antibacterial agents in medicinal chemistry
W Dan, J Dai - European journal of medicinal chemistry, 2020 - Elsevier
Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …
pharmacologically active agents because of their diverse mechanisms. This review provides …
Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is distinctly infective and
there is an ongoing effort to find a cure for this pandemic. Flavonoids exist in many diets as …
there is an ongoing effort to find a cure for this pandemic. Flavonoids exist in many diets as …
[HTML][HTML] Diverse molecular targets for chalcones with varied bioactivities
B Zhou, C Xing - Medicinal chemistry, 2015 - ncbi.nlm.nih.gov
Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …
biological activities that may benefit human health. The underlying mechanisms of action …
Nanoscale metal–organic layers detect mitochondrial dysregulation and chemoresistance via ratiometric sensing of glutathione and pH
X Ling, D Gong, W Shi, Z Xu, W Han… - Journal of the …, 2021 - ACS Publications
Mitochondrial dysregulation controls cell death and survival by changing endogenous
molecule concentrations and ion flows across the membrane. Here, we report the design of …
molecule concentrations and ion flows across the membrane. Here, we report the design of …
[HTML][HTML] Benzodioxole grafted spirooxindole pyrrolidinyl derivatives: Synthesis, characterization, molecular docking and anti-diabetic activity
A highly stereoselective, three-component method has been developed to synthesize
pyrrolidine and pyrrolizidine containing spirooxindole derivatives. The interaction between …
pyrrolidine and pyrrolizidine containing spirooxindole derivatives. The interaction between …
Mycobacterium tuberculosis Serine/Threonine Protein Kinases
Signal transduction is an essential activity of all living cells. Broadly defined, signal
transduction is the sensing of a signal or input and its conversion into an output or response …
transduction is the sensing of a signal or input and its conversion into an output or response …
Diaporisoindoles A–C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp. SYSU-HQ3
H Cui, Y Lin, M Luo, Y Lu, X Huang, Z She - Organic letters, 2017 - ACS Publications
Diaporisoindoles A (1) and B (2), two novel isoprenylisoindole alkaloids, and an unusual
diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone C (4) …
diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone C (4) …
Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents
Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two
series of novel pyrazole–coumarin chalcones and pyrazole–quinoline chalcones were …
series of novel pyrazole–coumarin chalcones and pyrazole–quinoline chalcones were …
New chalcone derivatives as effective against SARS‐CoV‐2 agent
Aims Flavonoids and related compounds, such as quercetin‐based antiviral drug Gene‐
Eden‐VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus 2 …
Eden‐VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus 2 …