Purinergic signaling has been established as an important feature of inflammation and
homeostasis. The expression of a number of P2 receptor subtypes in the gut has been …

Leishmaniasis is a neglected tropical disease affecting millions of people around the world
caused by organisms of the genus Leishmania. Parasite escape mechanisms of the immune …

P2X7R is a purinergic receptor with broad expression throughout the body, especially in
immune system cells. P2X7R activation causes inflammatory mediators to release, including …

Purpose.: The retinal pigment epithelium (RPE) is considered a primary site of pathology in
age-related macular degeneration (AMD), which is the most prevalent form of irreversible …

Progenitor cell therapies show great promise, but their potential for clinical applications
requires improved storage and transportation. Desiccated cells stored at ambient …

Extracellular adenosine triphosphate (ATP) is a second signal for the assembly of the NLR
family, pyrin domain-containing 3 (NLRP3) inflammasome, which form a framework to …

Hematopoietic stem and progenitor cells (HPCs) are a heterogenic population of cells used
to treat a number of human diseases. Multilineage differentiation is a required function in …

ATP activates the mouse P2X7 receptor and induces a nonselective-cation current in NG108-
15 cells. We investigated the effects of five receptor antagonists on the ATP-induced …

Одной из важнейших проблем современной медицины является высокая
распространенность патологии ЦНС. В развитых странах смертность от …

Age-related macular degeneration (AMD) is the leading cause of blindness among people
over the age of 50 worldwide. However, its exact causes and the underlying mechanisms …