The regulation and functions of DNA and RNA G-quadruplexes
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …
structures form through self-recognition of guanines into stacked tetrads, and considerable …
[HTML][HTML] Noncanonical DNA structures are drivers of genome evolution
KD Makova, MH Weissensteiner - Trends in Genetics, 2023 - cell.com
In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …
[HTML][HTML] Template and target-site recognition by human LINE-1 in retrotransposition
The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated
nearly one-third of the human genome and serves as an active source of genetic diversity …
nearly one-third of the human genome and serves as an active source of genetic diversity …
[HTML][HTML] Multimeric G-quadruplexes: A review on their biological roles and targeting
In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
Non-B DNA: a major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome
Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
[HTML][HTML] LINE-1 regulates cortical development by acting as long non-coding RNAs
Abstract Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that
constitute most of the genome's transcriptional output yet have still largely unknown …
constitute most of the genome's transcriptional output yet have still largely unknown …
[HTML][HTML] Machine learning model for sequence-driven DNA G-quadruplex formation
AB Sahakyan, VS Chambers, G Marsico, T Santner… - Scientific reports, 2017 - nature.com
We describe a sequence-based computational model to predict DNA G-quadruplex (G4)
formation. The model was developed using large-scale machine learning from an extensive …
formation. The model was developed using large-scale machine learning from an extensive …
[HTML][HTML] Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis
Background DNA is subject to constant chemical modification and damage, which
eventually results in variable mutation rates throughout the genome. Although detailed …
eventually results in variable mutation rates throughout the genome. Although detailed …
[HTML][HTML] L1 mosaicism in mammals: extent, effects, and evolution
GJ Faulkner, JL Garcia-Perez - TRENDS in Genetics, 2017 - cell.com
The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposable element that
has extensively colonized the mammalian germline. L1 retrotransposition can also occur in …
has extensively colonized the mammalian germline. L1 retrotransposition can also occur in …
G-Quadruplex DNA and RNA
D Yang - G-Quadruplex Nucleic Acids: Methods and Protocols, 2019 - Springer
Abstract G-quadruplexes (G4s) have become one of the most exciting nucleic acid
secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA …
secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA …