The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2
that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE …

Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

Stroke is a major cause of death worldwide, leading to serious disability. Post-ischemic
injury, especially in the cerebral ischemia-prone hippocampus, is a serious problem, as it …

There is considerable experimental evidence that the renin angiotensin system (RAS) plays
a central role in both hepatic fibrogenesis and portal hypertension. Angiotensin converting …

Although cerebral ischemia itself is associated with a high rate of disability, secondary
cerebral ischemia/reperfusion (I/R) injury following recanalization is associated with much …

Abstract Ginsenoside Rg1 (GS Rg1) is a glycosylated triterpenoid saponin extracted from
Panax ginseng. We aim to investigate the impact of GS Rg1 on protein aggregation and …

Nephrotoxicity is a rapid deterioration of kidney function due to exposure to nephrotoxic
drugs as gentamicin. Gentamicin increases the generation of reactive oxygen species (ROS) …

The human population is in the midst of battling a rapidly-spreading virus—Severe Acute
Respiratory Syndrome Coronavirus 2, responsible for Coronavirus disease 2019 or COVID …

Telmisartan (TEL) is an angiotensin II type 1 receptor blocker and a partial activator of
peroxisome proliferator-activated receptor-gamma (PPARγ), which regulates inflammatory …