Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues
into immunocompetent mice. Since a PDX model retains the characteristics of the primary …

Animal modeling for primary brain tumors has undergone constant development over the
last 60 years, and significant improvements have been made recently with the establishment …

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …

Pancreatic cancer remains one of the most lethal of malignancies and a major health
burden. We performed whole-genome sequencing and copy number variation (CNV) …

Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were
differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal …

Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a
poor prognosis. Here, we successfully established organoid lines derived from intrahepatic …

Glioblastoma is one of the most angiogenic human tumours and endothelial proliferation is a
hallmark of the disease. A better understanding of glioblastoma vasculature is needed to …

While the central nervous system is considered an immunoprivileged site and brain tumors
display immunosuppressive features, both innate and adaptive immune responses affect …

The" Side Population"(SP) discrimination assay is a flow cytometry method used to detect
stem cells based on the dye efflux properties of ABC transporters. We discuss the SP assay …