The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

The most common type of lung cancer is adenocarcinoma (ADC), comprising around 40% of
all lung cancer cases. In spite of achievements in understanding the pathogenesis of this …

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

Significance: Angiogenesis, the growth of new blood vessels from existing vessels, is an
important aspect of the repair process. Restoration of blood flow to damaged tissues …

Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Vascular endothelial growth factors (VEGFs) are master regulators of vascular development
and of blood and lymphatic vessel function during health and disease in the adult. It is …

Background Lenvatinib is an oral inhibitor of multiple receptor tyrosine kinases (RTKs)
targeting vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor …