The basal ganglia and the cerebellum are considered to be distinct subcortical systems that
perform unique functional operations. The outputs of the basal ganglia and the cerebellum …

Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …

Background Brain structure abnormalities throughout the course of Parkinson's disease
have yet to be fully elucidated. Objective Using a multicenter approach and harmonized …

Parkinson's disease (PD) is a progressive neurodegenerative disorder involving
dopaminergic neurons from the substantia nigra. The loss of dopaminergic neurons results …

While it is well documented that the motor system is more than a mere implementer of motor
actions, the possible applications of its cognitive side are still under-exploited, often …

The disruption of pathologically enhanced beta oscillations is considered one of the key
mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in …

Parkinson's disease (PD) pathogenesis may involve the epigenetic control of enhancers that
modify neuronal functions. Here, we comprehensively examine DNA methylation at …

Time perception is an essential element of conscious and subconscious experience,
coordinating our perception and interaction with the surrounding environment. In recent …

Summary α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in
Parkinson's disease (PD). Developing disease-modifying therapies requires animal models …

Background Our understanding of the etiology, pathophysiology, phenotypic diversity, and
progression of Parkinson's disease has stagnated. Consequently, patients do not receive …