Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells
G Campostrini, V Meraviglia, E Giacomelli… - Nature protocols, 2021 - nature.com
Tissue-like structures from human pluripotent stem cells containing multiple cell types are
transforming our ability to model and understand human development and disease. Here we …
transforming our ability to model and understand human development and disease. Here we …
Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration
G Campostrini, LM Windt, BJ van Meer… - Circulation …, 2021 - Am Heart Assoc
The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …
opportunities to study disease and produce cells that can be used for therapy in …
Modeling cardiovascular diseases with hiPSC-derived cardiomyocytes in 2D and 3D cultures
C Sacchetto, L Vitiello, LJ de Windt… - International journal of …, 2020 - mdpi.com
In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …
Engineering considerations of iPSC-based personalized medicine
Personalized medicine aims to provide tailored medical treatment that considers the clinical,
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
Reperfused vs. nonreperfused myocardial infarction: when to use which model
ML Lindsey, LE de Castro Brás… - American Journal …, 2021 - journals.physiology.org
There is a lack of understanding in the cardiac remodeling field regarding the use of
nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This …
nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This …
[HTML][HTML] Dual human iPSC-derived cardiac lineage cell-seeding extracellular matrix patches promote regeneration and long-term repair of infarcted hearts
Y Jiang, LL Zhang, F Zhang, W Bi, P Zhang, XJ Yu… - Bioactive Materials, 2023 - Elsevier
Human pluripotent stem cell-derived cardiovascular progenitor cells (hCVPCs) and
cardiomyocytes (hCMs) possess therapeutic potential for infarcted hearts; however, their …
cardiomyocytes (hCMs) possess therapeutic potential for infarcted hearts; however, their …
Human induced pluripotent stem cell-based platform for modeling cardiac ischemia
Ischemic heart disease is a major cause of death worldwide, and the only available therapy
to salvage the tissue is reperfusion, which can initially cause further damage. Many …
to salvage the tissue is reperfusion, which can initially cause further damage. Many …
Recent advances in cardiac tissue engineering for the management of myocardium infarction
Myocardium Infarction (MI) is one of the foremost cardiovascular diseases (CVDs) causing
death worldwide, and its case numbers are expected to continuously increase in the coming …
death worldwide, and its case numbers are expected to continuously increase in the coming …
Electrophysiological Changes of Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation
Ischemic heart disease is the most common cardiovascular disease and a major burden for
healthcare worldwide. However, its pathophysiology is still not fully understood, and human …
healthcare worldwide. However, its pathophysiology is still not fully understood, and human …