Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is
responsible for the epigenetic regulation of gene expression through specific methylation of …

Background Use of artificial intelligence to identify dermoscopic images has brought major
breakthroughs in recent years to the early diagnosis and early treatment of skin cancer, the …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Background: Using artificial intelligence (AI) with the concept of a deep learning-based
automated computer-aided diagnosis (CAD) system has shown improved performance for …

Methylation of histone H3 lysine-79 (H3K79) is an epigenetic mark for gene regulation in
development, cellular differentiation, and disease progression. However, how this histone …

Histone methylation, one of the most prominent epigenetic modifications, plays a vital role in
gene transcription, and aberrant histone methylation levels cause tumorigenesis. Histone …

Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells
upon oncogene activation. Cells undergoing OIS express a wide variety of secreted factors …

The reversible and precise temporal and spatial regulation of histone lysine
methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of …

Methylation of histone 3 at lysine 79 (H3K79) is one of the principal mechanisms involved in
gene expression. The histone methyltransferase DOT1L, which mono-, di-and trimethylates …