Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the
standard repertoire of techniques used by molecular biologists to investigate protein …

Alphaviruses are positive-strand RNA viruses, typically transmitted by mosquitoes between
vertebrate hosts. They encode four essential replication proteins, the non-structural proteins …

To better understand how positive-strand (+) RNA viruses assemble membrane-associated
replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected …

Alphaviruses are mosquito-borne viruses that cause serious disease in humans and other
mammals. Along with its mosquito vector, the Alphavirus chikungunya virus (CHIKV) has …

Positive-strand RNA viruses replicate their genomes in virus-induced membrane vesicles,
and the resulting RNA replication complexes are a major target for virus control. Nodavirus …

Hepatitis E virus (HEV), a major cause of acute viral hepatitis, is a single-stranded, positive-
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …

The alphaviruses are a widely distributed group of positive-sense, single stranded, RNA
viruses. These viruses are largely arthropod-borne and can be found on all populated …

Chikungunya virus (CHIKV) is a single positive-stranded RNA virus of the Togaviridae family
and Alphavirus genus, with a typical lipid bilayer envelope structure, and is the causative …

Chikungunya virus is a re-emerging arbovirus that has caused epidemic outbreaks in recent
decades. Patients in older age groups with high viral load and severe immunologic …

The Alphavirus genus includes viruses that cause encephalitis due to neuroinvasion and
viruses that cause arthritis due to acute and chronic inflammation. There is no approved …