The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …

Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …

Human cancers share properties referred to as hallmarks, among which sustained
proliferation, escape from apoptosis, and genomic instability are the most pervasive. The …

During genome replication, parental histones are recycled to newly replicated DNA with
their posttranslational modifications (PTMs). Whether sister chromatids inherit modified …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to
conveying the epigenetic program, it is still unclear how a defined chromatin domain is …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …

The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How
this is accomplished is still poorly understood. Using purified yeast replication proteins and …