From therapeutic drug monitoring to model‐informed precision dosing for antibiotics
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
[HTML][HTML] Management of sepsis and septic shock in the emergency department
F Gavelli, LM Castello, GC Avanzi - Internal and emergency medicine, 2021 - Springer
Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …
Emergency Department (ED) is the place where the first medical contact for septic patients is …
[HTML][HTML] Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a …
Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …
[HTML][HTML] Ventilator-associated pneumonia in patients with SARS-CoV-2-associated acute respiratory distress syndrome requiring ECMO: a retrospective cohort study
CE Luyt, T Sahnoun, M Gautier, P Vidal, S Burrel… - Annals of Intensive …, 2020 - Springer
Background The data on incidence, clinical presentation, and outcomes of ventilator-
associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) …
associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) …
Optimizing antimicrobial use: challenges, advances and opportunities
An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …
minimizing toxicity and development of drug resistance. There can be considerable …
[HTML][HTML] Diagnosis and management of infections caused by multidrug-resistant bacteria: guideline endorsed by the Italian Society of Infection and Tropical Diseases …
G Tiseo, G Brigante, DR Giacobbe, AE Maraolo… - International Journal of …, 2022 - Elsevier
Management of patients with infections caused by multidrug-resistant organisms is
challenging and requires a multidisciplinary approach to achieve successful clinical …
challenging and requires a multidisciplinary approach to achieve successful clinical …
A guide to therapeutic drug monitoring of β‐lactam antibiotics
AJ Fratoni, DP Nicolau, JL Kuti - Pharmacotherapy: The Journal …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …
[HTML][HTML] Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant gram-negative bacilli
M Zeng, J Xia, Z Zong, Y Shi, Y Ni, F Hu, Y Chen… - Journal of Microbiology …, 2023 - Elsevier
The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …
[HTML][HTML] Assessment of a PK/PD target of continuous infusion beta-lactams useful for preventing microbiological failure and/or resistance development in critically ill …
Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could
minimize the occurrence of microbiological failure and/or resistance development. This …
minimize the occurrence of microbiological failure and/or resistance development. This …
Continuous vs intermittent meropenem administration in critically ill patients with sepsis: the MERCY randomized clinical trial
G Monti, N Bradić, M Marzaroli, A Konkayev… - Jama, 2023 - jamanetwork.com
Importance Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …