Riboswitches are structured non-coding RNAs found in the 5′ UTR of important genes for
bacterial metabolism, virulence and survival. Upon the binding of specific ligands that can …

Antimicrobial drug resistance has emerged as a significant challenge in contemporary
medicine due to the proliferation of numerous bacterial strains resistant to all existing …

T-box riboswitches are unique riboregulators where gene regulation is mediated through
interactions between two highly structured RNAs. Despite extensive structural insights, how …

Amino acid availability in Gram-positive bacteria is monitored by T-box riboswitches. T-
boxes directly bind tRNAs, assess their aminoacylation state, and regulate the transcription …

RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging
avenue with the promise to expand the target space in the drug discovery field. From being …

T-box riboswitches are modular bacterial noncoding RNAs that sense and regulate amino
acid availability through direct interactions with tRNAs. Between the 5′ anticodon-binding …

Biofilm is a crucial virulence factor for microorganisms that causes chronic infection. After
biofilm formation, the bacteria present improve drug tolerance and multifactorial defense …

T-box riboswitches constitute a large family of tRNA-binding leader sequences that play a
central role in gene regulation in many gram-positive bacteria. Accurate inference of the …

The misuse and overuse of antibiotics have resulted in antibiotic resistance. However, there
are alternative approaches that could either substitute antibiotics or enhance their …

T‐box riboswitches are a widespread class of structured noncoding RNAs in Gram‐positive
bacteria that regulate the expression of amino acid‐related genes. They form negative …