Recent developments in the use of viruses as vaccine vectors have been facilitated by a
better understanding of viral biology. Advances occur as we gain greater insight into the …

Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Background We previously reported that dendritic cell-based mRNA vaccination plus
ipilimumab (TriMixDC-MEL IPI) results in an encouraging rate of tumor responses in patients …

Background. Vaccine development in human Plasmodium falciparum malaria has been
hampered by the exceptionally high levels of CD8+ T cells required for efficacy. Use of …

Previous work with small-animal laboratory models of tuberculosis has shown that
vaccination strategies based on heterologous prime-boost protocols using Mycobacterium …

Failure to establish an appropriate balance between pro-and anti-inflammatory immune
responses is believed to contribute to pathogenesis of severe malaria. To determine …

The smallpox vaccine Vaccinia was successfully used to eradicate smallpox, but although
very effective, it was a very reactogenic vaccine and responsible for the deaths of one or two …

Background This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an
experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein …

The difficulty of inducing protective immunity through antibodies against sporozoites led to
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …

Background Immunization with genetically engineered, attenuated malaria parasites (GAP)
that arrest during liver infection confers sterile protection in mouse malaria models. A first …