Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
Pathophysiology of stress granules: An emerging link to diseases
J Wang, Y Gan, J Cao, X Dong… - … Journal of Molecular …, 2022 - spandidos-publications.com
Under unfavorable environmental conditions, eukaryotic cells may form stress granules
(SGs) in the cytosol to protect against injury and promote cell survival. The initiation, mRNA …
(SGs) in the cytosol to protect against injury and promote cell survival. The initiation, mRNA …
Eosinophils and eosinophil-associated diseases: an update
JA O'Sullivan, BS Bochner - Journal of Allergy and Clinical Immunology, 2018 - Elsevier
The goal of this series is to offer a survey of the latest literature for clinicians and scientists
alike, providing a list of important recent advances relevant to the broad field of allergy and …
alike, providing a list of important recent advances relevant to the broad field of allergy and …
Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation
L Liu, Y Han, Z Zhang, Y Wang, Y Hu… - Acta Pharmacologica …, 2023 - nature.com
Parkinson's disease (PD) is a common neurodegenerative motor disorder characterized by
a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal …
a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal …
c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death
Oxidative stress-induced mitochondrial dysfunction and neuronal cell death have important
roles in the development of neurodegenerative diseases. Dynamin related protein 1 (Drp1) …
roles in the development of neurodegenerative diseases. Dynamin related protein 1 (Drp1) …
RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin
R Tian, J Tian, X Zuo, S Ren, H Zhang, H Liu… - Cell Death & …, 2023 - nature.com
The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with
multifunctional and multifaceted properties. By mediating protein-protein interactions …
multifunctional and multifaceted properties. By mediating protein-protein interactions …
[HTML][HTML] Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling
M Lachén-Montes, A González-Morales, I Iloro… - Neurobiology of …, 2019 - Elsevier
Olfactory dysfunction is one of the earliest features in Lewy-type alpha-synucleinopathies
(LTSs) such as Parkinson's disease (PD). However, the underlying molecular mechanisms …
(LTSs) such as Parkinson's disease (PD). However, the underlying molecular mechanisms …
Pivotal role of Fyn kinase in Parkinson's disease and levodopa-induced dyskinesia: a novel therapeutic target?
The exact etiology of Parkinson's disease (PD) remains obscure, although many cellular
mechanisms including α-synuclein aggregation, oxidative damage, excessive …
mechanisms including α-synuclein aggregation, oxidative damage, excessive …
Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia
T Santos-Silva, CFB Lopes, D Hazar Ülgen… - Schizophrenia …, 2024 - academic.oup.com
Abstract Background and Hypothesis Redox dysregulation has been proposed as a
convergent point of childhood trauma and the emergence of psychiatric disorders, such as …
convergent point of childhood trauma and the emergence of psychiatric disorders, such as …
Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect
Y Yu, Y Wu, H Yan, Z Xia, W Wen, D Liu… - Pharmaceutical …, 2021 - Taylor & Francis
Context Rosmarinic acid (RA) dose-dependently ameliorates acetaminophen (APAP)
induced hepatotoxicity in rats. However, whether RA hepatoprotective effect is by regulating …
induced hepatotoxicity in rats. However, whether RA hepatoprotective effect is by regulating …