Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Pathophysiology of stress granules: An emerging link to diseases

J Wang, Y Gan, J Cao, X Dong… - … Journal of Molecular …, 2022 - spandidos-publications.com
Under unfavorable environmental conditions, eukaryotic cells may form stress granules
(SGs) in the cytosol to protect against injury and promote cell survival. The initiation, mRNA …

Eosinophils and eosinophil-associated diseases: an update

JA O'Sullivan, BS Bochner - Journal of Allergy and Clinical Immunology, 2018 - Elsevier
The goal of this series is to offer a survey of the latest literature for clinicians and scientists
alike, providing a list of important recent advances relevant to the broad field of allergy and …

Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

L Liu, Y Han, Z Zhang, Y Wang, Y Hu… - Acta Pharmacologica …, 2023 - nature.com
Parkinson's disease (PD) is a common neurodegenerative motor disorder characterized by
a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal …

c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death

L Zhou, Q Zhang, P Zhang, L Sun, C Peng, Z Yuan… - Cell death & …, 2017 - nature.com
Oxidative stress-induced mitochondrial dysfunction and neuronal cell death have important
roles in the development of neurodegenerative diseases. Dynamin related protein 1 (Drp1) …

RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin

R Tian, J Tian, X Zuo, S Ren, H Zhang, H Liu… - Cell Death & …, 2023 - nature.com
The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with
multifunctional and multifaceted properties. By mediating protein-protein interactions …

[HTML][HTML] Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling

M Lachén-Montes, A González-Morales, I Iloro… - Neurobiology of …, 2019 - Elsevier
Olfactory dysfunction is one of the earliest features in Lewy-type alpha-synucleinopathies
(LTSs) such as Parkinson's disease (PD). However, the underlying molecular mechanisms …

Pivotal role of Fyn kinase in Parkinson's disease and levodopa-induced dyskinesia: a novel therapeutic target?

E Angelopoulou, YN Paudel, T Julian, MF Shaikh… - Molecular …, 2021 - Springer
The exact etiology of Parkinson's disease (PD) remains obscure, although many cellular
mechanisms including α-synuclein aggregation, oxidative damage, excessive …

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

T Santos-Silva, CFB Lopes, D Hazar Ülgen… - Schizophrenia …, 2024 - academic.oup.com
Abstract Background and Hypothesis Redox dysregulation has been proposed as a
convergent point of childhood trauma and the emergence of psychiatric disorders, such as …

Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect

Y Yu, Y Wu, H Yan, Z Xia, W Wen, D Liu… - Pharmaceutical …, 2021 - Taylor & Francis
Context Rosmarinic acid (RA) dose-dependently ameliorates acetaminophen (APAP)
induced hepatotoxicity in rats. However, whether RA hepatoprotective effect is by regulating …