Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …

In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …

Dysregulation of microRNAs (miRNAs) has been found in injured spinal cords after spinal
cord injury (SCI). Previous studies have shown that miR-133b plays an important role in the …

Background: Y-27632 is a potent ophthalmic drug for the treatment of ocular hypertension, a
globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic …

Abstract MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides
long, regulate gene expression by mediating translational inhibition or mRNA degradation …

Alterations in phospholipids have long been associated with spinal cord injury (SCI).
However, their specific roles and signaling cascades in mediating cell death and tissue …

Early blood retinal barrier (BRB) dysfunction induced by hyperglycemia was related to
increased pro-inflammatory activity of phospholipase A2 (PLA2) and the upregulation of …

Retrogradely-transported neurotrophin signaling plays an important role in regulating neural
circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to …

Medical management remains the cornerstone of glaucoma management despite advances
in the surgical or laser procedures. After a leap of almost two decades of the advent of …

Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A
profound understanding of the pathology and etiology of SCI is of great importance in …