[HTML][HTML] Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury
W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …
below the injured segment. SCI not only results in physical and psychological harm to …
Rho kinase inhibitors as a novel treatment for glaucoma and ocular hypertension
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …
[HTML][HTML] Exosomes derived from miR-133b-modified mesenchymal stem cells promote recovery after spinal cord injury
D Li, P Zhang, X Yao, H Li, H Shen, X Li… - Frontiers in …, 2018 - frontiersin.org
Dysregulation of microRNAs (miRNAs) has been found in injured spinal cords after spinal
cord injury (SCI). Previous studies have shown that miR-133b plays an important role in the …
cord injury (SCI). Previous studies have shown that miR-133b plays an important role in the …
[HTML][HTML] Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension
Background: Y-27632 is a potent ophthalmic drug for the treatment of ocular hypertension, a
globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic …
globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic …
The role of exosomal microRNAs in central nervous system diseases
Y Yu, K Hou, T Ji, X Wang, Y Liu, Y Zheng, J Xu… - Molecular and cellular …, 2021 - Springer
Abstract MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides
long, regulate gene expression by mediating translational inhibition or mRNA degradation …
long, regulate gene expression by mediating translational inhibition or mRNA degradation …
[HTML][HTML] Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury
Alterations in phospholipids have long been associated with spinal cord injury (SCI).
However, their specific roles and signaling cascades in mediating cell death and tissue …
However, their specific roles and signaling cascades in mediating cell death and tissue …
[HTML][HTML] Activation of the VEGF-A/ERK/PLA2 axis mediates early retinal endothelial cell damage induced by high glucose: new insight from an in vitro model of …
G Giurdanella, G Lupo, F Gennuso, F Conti… - International Journal of …, 2020 - mdpi.com
Early blood retinal barrier (BRB) dysfunction induced by hyperglycemia was related to
increased pro-inflammatory activity of phospholipase A2 (PLA2) and the upregulation of …
increased pro-inflammatory activity of phospholipase A2 (PLA2) and the upregulation of …
[HTML][HTML] Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery
Retrogradely-transported neurotrophin signaling plays an important role in regulating neural
circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to …
circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to …
Status of Rho kinase inhibitors in glaucoma therapeutics—An overview
BC Saha, R Kumari, R Kushumesh, A Ambasta… - International …, 2022 - Springer
Medical management remains the cornerstone of glaucoma management despite advances
in the surgical or laser procedures. After a leap of almost two decades of the advent of …
in the surgical or laser procedures. After a leap of almost two decades of the advent of …
[HTML][HTML] Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury
Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A
profound understanding of the pathology and etiology of SCI is of great importance in …
profound understanding of the pathology and etiology of SCI is of great importance in …