Doxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its
antibiotic properties, anti‐inflammatory properties and good safety profile. Over the past …

The relationship between dysbiosis and central nervous diseases has been proved in the
last 10 years. Microbial alterations cause increased intestinal permeability, and the …

Background Migraine is a severely debilitating disorder that affects millions of people
worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in …

PAR2 has a distinctive functional phenotype among an unusual group of GPCRs called
protease activated receptors, which self-activate after cleavage of their N-termini by mainly …

Osteoarthritis (OA) is a highly prevalent joint disorder blamed for pain and disability in older
individuals. It's commonly accepted that inflammation, apoptosis, autophagy and cellular …

Renal fibrosis is defined by excessive extracellular matrix (ECM) accumulation and is
associated with a decreased kidney function. Increased inflammation and infiltration of …

Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic
cancer and remains an obstacle to successful treatment. The antioxidant transcription factor …

A homeostatic function of the coagulation system in regard to hemostasis is well established.
Homeostasis of blood coagulation depends partially on protease activated receptor (PAR) …

Chronic kidney disease (CKD) is a clinical syndrome with many adverse sequelae and is
currently a major global health and economic burden. Regardless of aetiology, inflammation …

Proteinase-activated receptor-2 (PAR2), which modulates inflammatory responses, is
elevated in the central nervous system in multiple sclerosis (MS) and in its murine model …