The Ikaros family of proteins–comprising Ikaros, Aiolos, Helios, Eos and Pegasus–are zinc
finger transcription factors. These proteins participate in a complex network of interactions …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

The nuclear space is mostly occupied by chromosome territories and nuclear bodies.
Although this organization of chromosomes affects gene function, relatively little is known …

The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes
place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal …

Heterochromatin was first defined by Emil Heitz in 1928 by light microscopy. In the 1950s
electron microscopy studies revealed that heterochromatin preferentially localizes to the …

Maintenance of specific heterochromatic domains is crucial for genome stability. In
eukaryotic cells, a fraction of the tandem‐repeated ribosomal RNA (rRNA) genes is …

The open chromatin of embryonic stem cells (ESCs) condenses into repressive
heterochromatin as cells exit the pluripotent state. How the 3D genome organization is …

Global silencing of transcriptional activity in the oocyte genome occurs just before the
resumption of meiosis and is a crucial developmental transition at the culmination of …

The production of ribosomes constitutes a major biosynthetic task for cells. Eukaryotic small
and large ribosomal subunits are assembled in the nucleolus and independently exported to …

The nucleolus constitutes a prominent nuclear compartment, a membraneless organelle that
was first documented in the 1830s. The fact that specific chromosomal regions were present …