▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Ca 2+-dependent inactivation (CDI) of L-type Ca 2+ channels plays a critical role in
controlling Ca 2+ entry and downstream signal transduction in excitable cells. Ca 2+ …

Voltage-activated calcium channels regulate the intracellular calcium concentration and
contribute thereby to calcium signalling in numerous cell types. These channels are widely …

Metabolically 35 S-labeled calmodulin (CaM) was used to determine the CaM binding
properties of the cardiac ryanodine receptor (RyR2) and to identify potential channel …

L-type Ca 2+ channels possess a Ca 2+-dependent inactivation (CDI) mechanism, affording
feedback in diverse neurobiological settings and serving as prototype for unconventional …

Calcium ions are ubiquitous intracellular mediators of numerous cellular processes. One of
the main mechanisms of Ca2+ entry into the cell involves the opening of Ca2+ channels in …

Abstract L-type (α 1C) calcium channels inactivate rapidly in response to localized elevation
of intracellular Ca 2+, providing negative Ca 2+ feedback in a diverse array of biological …