Due to the wide use and key importance of mathematical models in process engineering,
experiment design is becoming an essential tool for the rapid building and validation of …

Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

The last two years have seen groundbreaking advances in natural language processing
(NLP) with the advent of applications like ChatGPT, Codex, and ChatSonic. This revolution …

This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

Abstract The Quality-by-Design (QbD) guidance issued by the US Food and Drug
Administration (FDA) has catalyzed the modernization of pharmaceutical manufacturing …

The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

Abstract The “Pharmaceutical Current Good Manufacturing Practices (CGMPs) for the 21st
Century—A Risk Based Approach” initiative announced by the FDA in August 2002 to …

In many industrial plants, development and implementation of advanced monitoring and
control techniques require real-time measurement of process quality variables. However, on …

In an industrial crystallization process, crystal shape strongly influences end-product quality
and functionality, as well as downstream processing. In addition, nucleation events, solvent …

Crystallization processes in the pharmaceutical industry are usually designed to obtain
crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process …