Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia.
In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is …

Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …

Abstract Peroxiredoxin 6 (Prdx6) is the prototype and the only mammalian 1-Cys member of
the Prdx family. Major differences from 2-Cys Prdxs include the use of glutathione (GSH) …

Reactive oxygen species (ROS) have emerged as regulators of key processes supporting
neuronal growth, function, and plasticity across lifespan. At normal physiological levels, ROS …

Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …

Dopamine dysregulation in schizophrenia may be associated with midbrain inflammation.
Previously, we found elevated levels of pro-inflammatory cytokine mRNAs in the post …

Major depressive disorder (MDD) is a leading cause of disability worldwide and results
tragically in the loss of almost one million lives in Western societies every year. This is due to …

Schizophrenia (SCZ) is the result of DNA alterations and environmental factors, which
together lead to differential protein expression and ultimately to the development of the …