Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic
organophosphate poisoning. They are effective nucleophiles that can restore the catalytic …

The first organophosphorus nerve agent was discovered accidently during the development
of pesticides, shortly after the first use of chemical weapons (chlorine, phosgene) on the …

Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the
blood–brain barrier, and has demonstrated excellent safety and tolerability properties in …

Six novel brominated bis-pyridinium oximes were designed and synthesized to increase
their nucleophilicity and reactivation ability of phosphorylated acetylcholinesterase (AChE) …

New furan, thiophene, and triazole oximes were synthesized through several-step reaction
paths to investigate their potential for the development of central nervous systems (CNS) …

In this review, the current progress in the research and development of butyrylcholinesterase
(BChE) reactivators is summarised and the advantages or disadvantages of these …

Background. People in different occupations are exposed to a variety of xenobiotics which
affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has …

Seven pyridoxal dioxime quaternary salts (1–7) were synthesized with the aim of studying
their interactions with human acetylcholinesterase (AChE) and butyrylcholinesterase …

Nerve agents are organophosphorus compounds (OPs) with very potent toxicity due to their
irreversible inhibition of the essential enzymeacetylcholinesterase (AChE; EC 3.1. 1.7) …

Organophosphorus compounds (eg nerve agents-sarin, VX or tabun) cause deleterious
intoxications via inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) …