A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …

The mitochondrial glycerophospholipid cardiolipin plays important roles in mitochondrial
biology. Most notably, cardiolipin directly binds to mitochondrial proteins and helps …

Successful inter-host transmission of most apicomplexan parasites requires the formation of
infective sporozoites within the oocysts. Unlike all other infective stages that are strictly …

Apoptosis is a highly programmed cell death strictly connected to the pathogenesis of many
human diseases, including neoplastic, neurodegenerative or cardiovascular diseases …

Toxoplasma gondii is among the most prevalent protozoan parasites, which infects a wide
range of organisms, including one-third of the human population. Its rapid intracellular …

Sphingosine-1-phosphate is a signaling molecule involved in the control of cell migration,
differentiation, survival and other physiological processes. This sphingolipid metabolite can …

For Trypanosoma brucei arginine and lysine are essential amino acids and therefore have
to be imported from the host. Heterologous expression in Saccharomyces cerevisiae …

The observation that the membranes of flagella are enriched in sterols and sphingolipids
has led to the hypothesis that flagella might be enriched in raft-forming lipids. However, a …