Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Snake venom toxins: Potential anticancer therapeutics

BC Offor, LA Piater - Journal of Applied Toxicology, 2024 - Wiley Online Library
Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …

[HTML][HTML] Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2

AE Siniavin, MA Streltsova, MA Nikiforova… - Cellular and Molecular …, 2021 - Springer
The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate
the symptoms and to prevent the spread of this disease. Previous studies demonstrated …

[HTML][HTML] Fifty Years of Animal Toxin Research at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS

V Tsetlin, I Shelukhina, S Kozlov… - International Journal of …, 2023 - mdpi.com
This review covers briefly the work carried out at our institute (IBCh), in many cases in
collaboration with other Russian and foreign laboratories, for the last 50 years. It discusses …

Assessment of snakebite burdens, clinical features of envenomation, and strategies to improve snakebite management in Vietnam

A Patra, AK Mukherjee - Acta tropica, 2021 - Elsevier
The sheer paucity of scientific documentation of herpetofauna in Vietnam and the
rudimentary healthcare response to snakebite have stimulated this review. Over six decades …

[HTML][HTML] Bibliometric analysis of literature in snake venom-related research worldwide (1933–2022)

F Sofyantoro, DS Yudha, K Lischer, TR Nuringtyas… - Animals, 2022 - mdpi.com
Simple Summary Around the world, snake envenomation poses a serious health risk.
Proteins with pharmacological effects are present in snake venom. Recent studies elaborate …

Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells

J Giribaldi, JJ Smith, CI Schroeder - Biotechnology Advances, 2021 - Elsevier
Animal venoms are a rich source of bioactive peptides that efficiently modulate key receptors
and ion channels involved in cellular excitability to rapidly neutralize their prey or predators …

FAT10 promotes the progression of bladder cancer by upregulating HK2 through the EGFR/AKT pathway

Y Zou, Y Du, C Cheng, X Deng, Z Shi, X Lu… - Experimental Cell …, 2021 - Elsevier
The ubiquitin-like protein FAT10 and the hexokinase protein HK2 play vital regulatory roles
in several cellular processes. However, the relationship between these two proteins and …

[HTML][HTML] Pllans–II Induces Cell Death in Cervical Cancer Squamous Epithelial Cells via Unfolded Protein Accumulation and Endoplasmic Reticulum Stress

A Montoya-Gómez, N Rivera Franco… - Molecules, 2022 - mdpi.com
Due to the lack of chemotherapeutic drugs that selectively affect cervical cancer cells,
natural sources such as snake venom are currently being investigated for molecules with …

[HTML][HTML] Functional Characterization and Anti-Tumor Effect of a Novel Group II Secreted Phospholipase A2 from Snake Venom of Saudi Cerastes cerates gasperetti

M Alonazi, N Krayem, MG Alharbi, AIA Khayyat… - Molecules, 2023 - mdpi.com
Secreted phospholipases A2 are snake-venom proteins with many biological activities,
notably anti-tumor activity. Phospholipases from the same snake type but different …