In recent years, a number of bioorthogonal reactions have been developed, exemplified by
click chemistry, that enable the efficient formation of a specific product, even within a highly …

In the last decade, glycan microarrays have revolutionized the analysis of the specificity of
glycan-binding proteins (GBPs), providing information that simultaneously illuminates the …

Our understanding of the different glycoconjugates present on cells, proteins and entire
organisms is lagging far behind advances in genomics and proteomics. Carbohydrate …

In the last decade, carbohydrate microarrays have been core technologies for analyzing
carbohydrate-mediated recognition events in a high-throughput fashion. A number of …

Glycomics is emerging as a new field for the biology of complex glycoproteins and
glycoconjugates. The lack of versatile glycan-labeling methods has presented a major …

Carbohydrates have been shown to play important roles in biological processes. The pace
of development in carbohydrate research is, however, relatively slow due to the problems …

Abstract Information contained in the mammalian glycome is decoded by glycan-binding
proteins (GBPs) that mediate diverse functions including host-pathogen interactions, cell …

Therapeutic vaccines derived from carbohydrate antigen–adjuvant combinations are a
promising approach for cancer immunotherapy. One of the critical limitations in this area is …

Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …

Globo H (GH) is a hexasaccharide specifically overexpressed on a variety of cancer cells
and therefore, a good candidate for cancer vaccine development. To identify the optimal …