Novel agents for the pharmacological treatment of alcohol use disorder
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
Therapeutic targeting of 3′, 5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
GS Baillie, GS Tejeda, MP Kelly - Nature reviews Drug discovery, 2019 - nature.com
Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …
pursued as therapeutic targets for several diseases, including those affecting the nervous …
[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies
Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …
Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial
Ibudilast, a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE)-3,-
4,-10, and-11, and macrophage migration inhibitory factor (MIF), shows promise as a novel …
4,-10, and-11, and macrophage migration inhibitory factor (MIF), shows promise as a novel …
Overview of alcohol use disorder
HR Kranzler - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
Alcohol is regularly consumed throughout most of the world, including by nearly half the US
population age 12 or older. Heavy drinking, which is also common, contributes to multiple …
population age 12 or older. Heavy drinking, which is also common, contributes to multiple …
Alcohol, tobacco, and marijuana consumption is associated with increased odds of same-day substance co-and tri-use
Background Little is known about event-level patterns of marijuana co-or tri-use with alcohol
and tobacco. Thus, the study goal was to examine patterns of same-day alcohol, cigarette …
and tobacco. Thus, the study goal was to examine patterns of same-day alcohol, cigarette …
Oxidative stress and neuroinflammation as a pivot in drug abuse. A focus on the therapeutic potential of antioxidant and anti-inflammatory agents and biomolecules
P Berríos-Cárcamo, M Quezada, ME Quintanilla… - Antioxidants, 2020 - mdpi.com
Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …
Targeting persistent changes in neuroimmune and epigenetic signaling in adolescent drinking to treat alcohol use disorder in adulthood
Studies universally find early age of drinking onset is linked to lifelong risks of alcohol
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …
Immune treatments for alcohol use disorder: A translational framework
While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …
response, such as that resulting from sustained heavy alcohol use, can damage the host …